Gene regulatory networks (GRNs) consist of physical and regulatory interactions between transcription factors (TFs) and their DNA targets. While many disease-associated DNA mutations have been identified in protein coding regions of the human genome, the vast majority of these mutations … Continue reading →
Gene regulatory networks (GRNs) comprising interactions between transcription factors (TFs) and regulatory loci control development and physiology. Numerous disease-associated mutations have been identified, the vast majority residing in non-coding regions of the genome. As current GRN mapping methods test one … Continue reading →
Dr. Lesley MacNeil has left the lab to start her own lab as an Assistant Professor in the Department of Biochemistry and Biomedical Sciences at the Farncombe Family Digestive Health Research Institute at McMaster University in Hamilton, Ontario, Canada. We … Continue reading →
RNAi has become an essential tool in C. elegans research. This unit describes procedures for RNAi in C. elegans by microinjecting with dsRNA, feeding with bacteria expressing dsRNA, and soaking in dsRNA solution, as well as high-throughput methods for RNAi-based … Continue reading →
Nederland in ideeën 2015 Why Some People Get Sick and Others Don’t by Dr. Marian Walhout Download the chapter here (pdf) NOTE THAT THE ARTICLE IS IN DUTCH … Continue reading →
Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans … Continue reading →
Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control … Continue reading →
