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Human Gene-Centered Transcription Factor Networks for Enhancers and Disease Variants

Walhout Lab Posted on April 24, 2015 by adminOctober 30, 2015

Gene regulatory networks (GRNs) comprising interactions between transcription factors (TFs) and regulatory loci control development and physiology. Numerous disease-associated mutations have been identified, the vast majority residing in non-coding regions of the genome. As current GRN mapping methods test one … Continue reading →

Posted in Publication | Tagged Enhancers, Gene Regulatory Networks, Protein-DNA Interation Networks, Transcription Factors, Yeast One-Hybrid

Good Luck Lesley!

Walhout Lab Posted on February 25, 2015 by adminOctober 30, 2015

Dr. Lesley MacNeil has left the lab to start her own lab as an Assistant Professor in the Department of Biochemistry and Biomedical Sciences at the Farncombe Family Digestive Health Research Institute at McMaster University in Hamilton, Ontario, Canada. We … Continue reading →

Posted in Alumni

Method: RNA Interference in Caenorhabditis elegans

Walhout Lab Posted on February 19, 2015 by adminOctober 30, 2015

RNAi has become an essential tool in C. elegans research. This unit describes procedures for RNAi in C. elegans by microinjecting with dsRNA, feeding with bacteria expressing dsRNA, and soaking in dsRNA solution, as well as high-throughput methods for RNAi-based … Continue reading →

Posted in Method | Tagged Caenorhabditis elegans, RNAi

Dr. Walhout Contributes a Chapter to the Book Netherlands in Ideas 2015

Walhout Lab Posted on November 11, 2014 by adminOctober 30, 2015

Nederland in ideeën 2015 Why Some People Get Sick and Others Don’t by Dr. Marian Walhout   Download the chapter here (pdf) NOTE THAT THE ARTICLE IS IN DUTCH … Continue reading →

Posted in Book Chapter

Review: Worms, bacteria, and micronutrients: an elegant model of our diet

Walhout Lab Posted on August 28, 2014 by adminNovember 2, 2015

Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans … Continue reading →

Posted in Review | Tagged Caenorhabditis elegans, Cobalamin, Folate, Gut Microbiota, Metabolism, Micronutrients, RNAi, Vitamin B12, Vitamin B9

Review: C. elegans metabolic gene regulatory networks govern the cellular economy

Walhout Lab Posted on May 1, 2014 by adminNovember 2, 2015

Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control … Continue reading →

Posted in Review | Tagged Caenorhabditis elegans, Gene Regulatory Networks, Metabolic Networks, Metabolism, microRNA, NHR, Nuclear Hormone Receptors

Ph.D. Candidate Emma Watson wins 2014 Harold M. Weintraub Graduate Student Award

Walhout Lab Posted on April 30, 2014 by adminApril 30, 2014

Walhout lab graduate student Emma Watson received the 2014 Harold M. Weintraub Graduate Student Award for research into the complex interactions between diet, gene expression and physiology. Only 13 students from North America were chosen for the prestigious award sponsored … Continue reading →

Posted in Awards

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Marian Walhout, Ph.D.
The Maroun Semaan Chair in Biomedical Research
Co-Director, Program in Systems Biology
Professor, Program in Molecular Medicine

University of Massachusetts Medical School
Albert Sherman Center, Room 5.1051
386 Plantation St.
Worcester, MA 01605
E-mail: Marian Walhout

Missy Gardella, Assistant to Dr. Walhout
Albert Sherman Center, Room 5.1053
Phone: 508-856-3601
Fax: 508-856-2105

Sarah VanVoorhis, Ordering/Billing
Phone: 774-455-3694

Lab Phone: 508-856-4367

News/Events

January 8, 2019
A Persistence Detector for Metabolic Network Rewiring in an Animal published in Cell Reports

November 19, 2018
Welcome to Visiting Scholar Rui Gao!

November 19, 2018
Welcome rotation student Vinita Chaudhari!

October 23, 2018
Welcome to WPI undergraduate Akshaye Shah who will be performing his major qualifying project in our lab.

September 17, 2018
Welcome rotation student Kaitlyn Valla!

September 17-19, 2018
CCSP/PSB Retreat
Beauport Hotel, Gloucester, MA

June 28-July 1, 2018
Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans meeting in Madison, Wisconsin, USA. Lecture by Dr. Walhout, oral presentation by post-doc Yan Zhang, and poster presentation by post-doc Jote Bulcha.

June 18, 2018
Shivani Nanda joins the lab as a graduate student. Welcome Shivani!

June 14-17, 2018
C. elegans development, cell biology, and gene expression conference in Barcelona, Spain. Lecture by Dr. Walhout and poster presentation by grad student Gabby Giese.

June 14, 2018
Congratulations to doctoral candidate Brent Horowitz for passing his qualifying exam!

May 29, 2018
Welcome to our summer interns, Charles Sanderson from Worcester Polytechnic Institute, and Yomari Rivera from Worcester Technical High School!

April 20, 2018
Dr. Walhout publishes a Perspective on trigenic interactions in Science

April 9, 2018
Xuhang Li and Gabby Giese join the lab as graduate students. Welcome!

March 20, 2018
MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development C. elegans published in Cell Reports

February 20, 2018
Bienvenue à post-doctoral fellow Cédric Diot!

February 5, 2018
Welcome rotation students Levi Ali and Shivani Nanda!

January 18, 2018
Methods: Gateway Recombinational Cloning published in Cold Spring Harbor Protocols

November 27, 2017
Welcome rotation students Gabrielle Giese and Xuhang Li!

October 13, 2017
Worms, bugs and drugs: Caenorhabditis elegans as a model for host-microbe-drug interactions published in Current Opinion in Chemical Biology

September 11-13, 2017
CCSB/PSB Retreat, Beauport Hotel, Gloucester, MA

September 5, 2017
Dr. Walhout receives $4.1 million outstanding investigator award from NIH

July 1, 2017
Welcome to our summer intern Riya Shankar from St. Marks School in Southborough, MA!

June 21-25, 2017
21st International C. elegans Conference, University of California, Los Angeles
Poster presentations by Sushila Bhattacharya (June 22), Huimin Na (June 23), and Jingyan Zhang (June 24). Oral presentation by Aurian-Garcia Gonzalez (June 25). Workshop presentations by Marian Walhout (June 22 & 23) and Safak Yilmaz (June 23).

June 1, 2017
Welcome to our summer intern Kaela Fitch from Endicott College in Beverly, MA!

May 30, 2017
Graduate student Zeynep Mirza joins the lab to be co-supervised by Marian Walhout and Victor Ambros. Welcome Zeynep!

April 20, 2017
Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics published in Cell

April 12, 2017
Dr. Walhout appointed to endowed chair

March 31, 2017
Video of keynote lecture by Marian Walhout from the CSHL meeting Systems Biology: Networks

March 25, 2017
PSB Curling Bonspiel
Wayland, MA

March 20, 2017
Graduate student Brent Horowitz joins the lab. Welcome Brent!

March 10, 2017
PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions published in Translation

February 13, 2017
C. elegans and its bacterial diet as a model for systems-level understanding of host–microbiota interactions published in Current Opinion in Biotechnology

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